Pharma Focus Europe

Research Insights

The Research Insights section focuses on the latest breakthroughs in medicine and science, as well as the laboratory works around the world. Research insights directly from these labs add tremendous value to our readers.

Radiation Enhancement Using Focussed Ultrasound-stimulated Microbubbles for Breast Cancer: A Phase 1 Clinical Trial

Radiotherapy plays a pivotal role in breast cancer management It is typically administered in the adjuvant setting to reduce locoregional recurrence or in a palliative scenario to alleviate symptoms such as pain or bleeding

Analysis of the Nischarin Expression Across Human Tumor Types Reveals Its Context-dependent Role and a Potential as a Target for Drug Repurposing in Oncology

Nischarin was first identified in the year as a novel protein interacting with the integrin subunit involved in the control of cell migration Soon it was recognized

A Multimodal Transformer Network for Protein-small Molecule Interactions Enhances Predictions of Kinase Inhibition and Enzyme-substrate Relationships

Predicting interactions between proteins and small molecules is a longstanding challenge in biological and medical research and it plays a crucial role in the discovery of new drugs

PAI-1 Mediates Acquired Resistance to MET-targeted Therapy in Non-small Cell Lung Cancer

As a leading cause of the incidence and mortality of cancer prevalence worldwide lung cancer requires a comprehensive understanding of the nature and appropriate management of the disease

Acteoside and Isoacteoside Alleviate Renal Dysfunction and Inflammation in Lipopolysaccharide-induced Acute Kidney Injuries Through Inhibition of Nf-κb Signaling Pathway

Acute kidney injury is a severe clinical and multifactorial illness characterized by a sudden loss of renal functioning It is marked by impaired renal tubular reabsorption and decreased

Evaluation of Genotoxic Effect via Expression of DNA Damage Responsive Gene Induced by Ivermectin on MDBK Cell Line

Ivermectin is a semisynthetic macrocyclic compound which is effective against numerous parasitic diseases including onchocerciasis It has been reported to be effective against symptomatic alleviation caused by Onchocerca

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

The ongoing pandemic of Severe Acute Respiratory Syndrome Coronavirus infections has taken a devastating toll on American Indian and Alaskan Native populations with hospitalization and death rate ratios for COVID

Effects of COVID-19 Vaccine Safety Framing on Parental Reactions

Despite the benefits and worldwide approval use of COVID vaccination for children parents still remain a high level of vaccine hesitancy due to concerns about vaccine safety

Regional Variations in Vaccination Against COVID-19 in Germany

In order to curb the SARSCoV virus vaccines were developed as quickly as possible in and enormous vaccination campaigns started by the end of in the industrialized countries In the first months of

Identification of Differentially Expressed mRNA/lncRNA Modules in Acutely Regorafenib-treated Sorafenib-resistant Huh7 Hepatocellular Carcinoma Cells

The multikinase inhibitor sorafenib is the standard firstline treatment for advanced hepatocellular carcinoma but many patients become sorafenibresistant This study investigated the efficacy of another kinase inhibitor

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